A PRELIMINARY REPORT ON THE EFFICACY OF A SINGLE ADMINISTRATION OF A PLATELET CONCENTRATE (V-PET) FOR THE MANAGEMENT OF NATURALLY OCCURRING OSTEOARTHRITIS

Comunicación Libre

Traumatología

(1) Divisão de Medicina Veterinária, Guarda Nacional Republicana
(2) ICAAM – Instituto de Ciências Agrárias e Ambientais Mediterrâneas – Universidade de Évora
(3) Faculty of Veterinary Medicine, University of Lisbon
(4) Interdisciplinary Centre for Research in Animal Health (CIISA)
(5) Anjos of Assis Veterinary Medicine Centre

João Carlos Alves (1)
João Carlos Alves (2)
Ana Santos (1)
Patrícia Jorge (1)
Catarina Lavrador (2)
L. Miguel Carreira (3)
L. Miguel Carreira (4)
L. Miguel Carreira (5)

RESUMEN CORTO - SHORT SUMMARY

The goal of this study was to describe the use and effectiveness of intra-articular a platelet concentrate (V-PET) in the management of naturally occurring hip osteoarthritis (OA) in an animal model. Twelve working dogs were treated with 3ml of platelet concentrate per hip, prepared with V-PET. Evaluations were conducted at T0 (before treatment), T1 (15 days after treatment), T2, T3, T4 and T5 (1, 2, 3, and 4 months after treatment). Response to treatment was evaluated with the Canine Brief Pain Inventory (divided in Pain Severity Score (PSS) and Interference Score (PIS)), Liverpool Osteoarthritis in Dogs (LOAD), Canine Orthopedic Index (divided in stiffness (Stiff), function, gait and quality of life (QOL)) and Hudson Visual Analogue Scale (HVAS). No other medication was administered.

When comparing each moment with T0, significant differences where found at T1 (p=0.03 for HVAS and PIS, p=0.00 for PSS and Gait, p=0.05 for Function, p=0.01 for QOL), T2 (p=0.00 for PSS, PIS and Gait, p=0.03 for Function and LOAD), T3 (p=0.01 for HVAS, PSS and Gait, p=0.05 for PIS and QOL, p=0.03 for Function), T4 (p=0.02 for PSS) and T5 (p=0.01 for PSS and Function, p=0.03 for Gait).

Intra-articular V-PET is a good treatment option for OA. More studies are required.

BIBLIOGRAFÍA

1.        Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: A disease of the joint as an organ. Arthritis Rheum. 2012;64(6):1697-1707. doi:10.1002/art.34453.

2.        Anderson KL, O’Neill DG, Brodbelt DC, et al. Prevalence, duration and risk factors for appendicular osteoarthritis in a UK dog population under primary veterinary care. Sci Rep. 2018;8(1):5641. doi:10.1038/s41598-018-23940-z.

3.        Meeson RL, Todhunter RJ, Blunn G, Nuki G, Pitsillides AA. Spontaneous dog osteoarthritis — a One Medicine vision. Nat Rev Rheumatol. April 2019. doi:10.1038/s41584-019-0202-1.

4.        Lascelles BDX, Brown DC, Maixner W, Mogil JS. Spontaneous painful disease in companion animals can facilitate the development of chronic pain therapies for humans. Osteoarthr Cartil. 2018;26(2):175-183. doi:10.1016/j.joca.2017.11.011.

5.        Nguyen RT, Borg-Stein J, McInnis K. Applications of Platelet-Rich Plasma in Musculoskeletal and Sports Medicine: An Evidence-Based Approach. PM&R. 2011;3(3):226-250. doi:10.1016/j.pmrj.2010.11.007.

6.        Boswell SG, Cole BJ, Sundman EA, Karas V, Fortier LA. Platelet-rich plasma: A milieu of bioactive factors. Arthrosc - J Arthrosc Relat Surg. 2012;28(3):429-439. doi:10.1016/j.arthro.2011.10.018.

7.        Fahie MA, Ortolano GA, Guercio V, et al. A randomized controlled trial of the efficacy of autologous platelet therapy for the treatment of osteoarthritis in dogs. J Am Vet Med Assoc. 2013;243(9):1291-1297. doi:10.2460/javma.243.9.1291.

8.        Franklin SP, Cook JL. Prospective trial of autologous conditioned plasma versus hyaluronan plus corticosteroid for elbow osteoarthritis in dogs. Can Vet J = La Rev Vet Can. 2013;54(9):881-884. doi:papers3://publication/uuid/8CA2261E-0561-44E6-9F04-4C69528569E0.

9.        Walton B, Cox T, Innes J. ‘How do I know my animal got better?’ – measuring outcomes in small animal orthopaedics. In Pract. 2018;40(2):42-50. doi:10.1136/inp.k647.

10.      Brown DC. The Canine Orthopedic Index. Step 2: Psychometric Testing. Vet Surg. 2014;43(3):241-246. doi:10.1111/j.1532-950X.2014.12141.x.

11.      Hudson JT, Slater MR, Taylor L, Scott HM, Kerwin SC. Assessing repeatability and validity of a visual analogue scale questionnaire for use in assessing pain and lameness in dogs. Am J Vet Res. 2004;65(12):1634-1643. doi:10.2460/ajvr.2004.65.1634.

12.      Brown DC, Bell M, Rhodes L. Power of treatment success definitions when the Canine Brief Pain Inventory is used to evaluate carprofen treatment for the control of pain and inflammation in dogs with osteoarthritis. Am J Vet Res. 2013;74(12):1467-1473. doi:10.2460/ajvr.74.12.1467.

13.       Alves JC, Santos AM. Evaluation of the Effect of Mesotherapy in the Management of Osteoarthritis-Related Pain in a Police Working Dog Using the Canine Brief Pain Inventory. Top Companion Anim Med. 2017;32(1):41-43. doi:10.1053/j.tcam.2017.07.002.