(2) ICAAM – Instituto de Ciências Agrárias e Ambientais Mediterrâneas – Universidade de Évora
(3) Faculty of Veterinary Medicine, University of Lisbon (FMV/ULisboa)
(4) Interdisciplinary Centre for Research in Animal Health (CIISA)
(5) Anjos of Assis Veterinary Medicine Centre (CMVAA)
João Carlos Alves (2)
Ana Santos (1)
Patrícia Jorge (1)
Catarina Lavrador (2)
L. Miguel Carreira (3)
L. Miguel Carreira (4)
L. Miguel Carreira (5)
To describe the use and effectiveness of intra-articular triamcinolone acetonide (TA), hyaluronan (HA) and a combination of both (TA+HA), thirty police working dogs with naturally occurring hip osteoarthritis (OA) were selected. Sample comprised 6 females and 24 males, with a mean age of 6 years old and weight of 33.3 kg. Animals were randomly divided in three groups and treated with either a single administration of 20mg of TA (GT), 20mg of HA (GH) or a combination of 20mg of TA and 20mg of HA (GTH) per hip joint.
Response to treatment, measured by the Canine Brief Pain Inventory (CBPI) and the Hudson Visual Analogue Scale (HVAS), was evaluated at T0 (before treatment), T1 (after 15 days), T2, T3, T4, T5 and T6 (after 1, 2, 3, 4 and 5 months respectively). Results were compared using a Kruskal-Wallis test or a Wilcoxon signed ranks test.
Comparing results of the different time points considered with T0, significant differences were observed in GH at T1 for HVAS (p=0.03) and PIS (p=0.04); and in GTH at T1 (p=0.05 for HVAS and p<0.05 for PIS), T2 (p<0.04 for PIS), T3 (p<0.03 for HVAS and p=0.05 for PIS), T4 (p<0.03 for HVAS and p<0.05) and T5 (p<0.05 for HVAS). No significant differences were found between groups when comparing results by time point. Intra-articular TA and HA may be a treatment option for dogs with naturally occurring OA, but their simultaneously use seems to improve the results. Further studies are required.
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