(2) Department of clinical sciences, Université de Toulouse, ENVT, Toulouse, France
(3) Synelvia, Labège, France
Eloy Castilla-castano (2)
Line-alice Lecru (2)
Nicolas Amalric (3)
Charline Pressanti (2)
Marie-chrsitine Cadiergues (1)
Dietary supplementation with ω-3 essential fatty acids (EFA) has a beneficial effect on dog’s skin and coat quality. However, little is known about necessary dose and treatment duration. The objective was to determine the kinetics of hair and skin quality improvement after starting n-3 EFA supplementation with Agepi®ω3 (IVP, MP Labo, France), the lasting of the effects after its withdrawal of the diet and its association with erythrocyte membrane (EM) and hair shafts lipid content. Twenty-four hunting dogs with poor hair quality (same owner, environment and diet at baseline) were enrolled in this prospective, randomized, double-blinded, placebo controlled study. Dogs received 1 capsule/10 kg of placebo or IVP daily for 90 days (1 capsule IVP = 110 mg eicosapentaenoic acid (EPA)/68 mg docosahexanoic acid (DHA)). Clinical assessment (Skin Seborrheic Index, SSI) and blood and hair lipid samples were performed at days 30, 60, 90, 120, 150 and 180; SSI was significantly reduced in the treatment group from day 30 reaching a plateau after 2 months and returning to baseline levels 90 days after withdrawal. EPA and DHA content on EM increased significantly from day 30 and decreased rapidly after withdrawal in the treatment group. Total lipid content on hair shaft increased until day 60 and remained stable 90 days after withdrawal. No side effects were observed. The hair and skin improvement after IVP supplementation is maximal after two months, lasts for one month after withdrawal and is associated with marked increase of EPA and DHA content in EM and total lipid content on hairs shafts.
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