(2) Universitat Autonoma de Barcelona, Barcelona, Spain
(3) Isoquimen SL, Sant Feliu de Codines, Spain
Lluis Ferrer (2)
Gloria Nejar (3)
Marina Gatellet (1)
Elodie Ollivier (1)
Claudine Zemirline (1)
Ophytrium is a new purified natural ingredient, selected for its high tolerance and simultaneous threefold action on skin barriers. Seboliance is a natural seboregulating ingredient. Two innovative topical products containing these two ingredients were developed for dogs with seborrheic disorders: one shampoo and one leave-on mousse. To evaluate the tolerance of these new formulas, no guidelines are currently available. An original protocol was designed in acute conditions of exposure.
Twenty-four healthy adult kennel beagle dogs were randomized into two groups of twelve. The first group served as control. The second group received one bath with shampoo (regular dose, 10 min stand-time) at D0, and four mousses (twice the regular dose, left side only) per week for three consecutive weeks. A complete physical examination was performed on days 0, 7, 14, and 21 by a veterinary dermatologist. In addition, skin was observed daily except on Sundays, and lesions (if any) were scored according to type, intensity, and extent. Mean scores were calculated for each group.
No alteration of animals general health was detected. Majority of the local findings were mild/localized/transient erythema and excoriations, and rare alopecia and papules, all likely related to normal behavior of kennel dogs. No differences were observed between the two groups and both sides of the dog, neither in daily mean scores evolution, nor in cumulative mean scores at the end of the study.
In conclusion, shampoo and mousse containing Ophytrium and Seboliance were safe and very well tolerated in dogs under these acute experimental conditions.
BIBLIOGRAFÍA
-
