EFFICACY OF A TOPICAL SPRAY FOR THE TREATMENT OF CUTANEOUS SURFACE AND SUPERFICIAL PYODERMAS AND MALASSEZIA OVERGROWTH SYNDROME IN DOGS

Comunicación Libre

Dermatología

(1) Université de Lyon VetAgro Sup - UP Interactions Cellules Environnement

Didier Pin (1)
Marion Mosca (1)

RESUMEN CORTO - SHORT SUMMARY

A topical spray composed of essential oils of lavendin and manuka, N-acetylcysteine and plant-extracted essentials fatty acids (PYOclean^®Spray, Dermoscent^®, LDCA, France) has been studied for the treatment of superficial bacterial skin infections. Eleven dogs were presented because of moderate to severe pruritus affecting the interdigital spaces, perivulvar region, groin and axillae and/or abdominal region. Complementary examinations revealed bacterial overgrowth (BOG) and/or Malaseziaovergrowth (MOG). No underlying cause was found. Treatment consisted of antiseptic shampoos followed by moisturizers twice a week, associated with application of PYOclean^®Spray twice a day for 3 weeks. Clinical efficacy of the spray was assessed at day 10 and day 21 based on a score for lesion extent (0=absence to 2=multiple sites) and gravity (0=absence to 4=severe). Satisfaction of the veterinarian and the owners regarding the global efficacy and soothing effect on pruritus was evaluated based on a score between 0 (very unsatisfied) and 5 (very satisfied). There was a significant score reduction for lesion extent at D21 (p=0.03) and lesion gravity at D10 (p=0.0002) and D21 (p=0.004). Product efficacy was viewed satisfying for both owners and veterinarians with an average score of 3.45 and 3.27 respectively. It was concluded by the investigators that PYOclean^®Spray is an effective adjunctive topical treatment for BOG/superficial pyodermas and MOG when used twice a day during a 21-day treatment program.

BIBLIOGRAFÍA

1. Murayama N, Nagata M, Terada Y, shibata S, Fukata T Efficacy of a surgical scrub including 2% chlorhexidine acetate for canine superficial pyoderma. Vet Dermatol 2010; 21: 586-592.
2. Loeffler A, Cobb MA, Bond R. Comparison of a chlorhexidine and a benzoyl peroxyde shampoo as sole treatment in canine superficial pyodermas. Vet Record 2011; 169(10): 249-254.
3. Borio S, Colombo S, La Rosa G, De Lucia M, Damborq P, Guardabassi L. Effectiveness of a combined (4% chlorhexidine digluconate shampoo and solution) protocol in MRS and non MRS canine superficial pyoderma: a randomized, blinded, antibiotic-controlled study. Vet Dermatol 2015; 26(5): 339-344.
4. Bensignor E, Fabries L, Bailleux L. A split-body, randomized, blinded study to evaluate the efficacy of a topical spray composed of essential oils and essential fatty acids from plant extracts with antimicrobial properties. Vet Dermatol 2016; 27(6): 464-e123.
5. Dinicola S, De Grazia S, Carlomagno G, Pintucci JP. N-acetylcysteine as powerfulmolecule to destroy bacterial biofilms. A systematic review. Eur Rev Med PharmacolSci 2014; 18(19): 2942-8.
6. May ER, Conklin KA, Bemis DA.Antibacterial effect of N-acetylcysteine on common canine otitis externa isolates. Vet Dermatol 2016; 27(3): 199-90.