The best way to win a war is to know your enemy! Cancer is a complex disease. We can say another way of a living form! In this lecture we will go in a very practical and accessible way trough the hallmarks of cancer: What is the current knowledge about cancer? What are the mechanisms of cancer survival and therapeutic evasion? Cancer specific metabolism and auto-sufficiency? What are the tricks cancer uses to metastize? At the end we will finish with a brief insight what can be the future approach to treat tumors. If you want to know the enemy, don't miss it!