Paper:

RESUMEN CORTO - SHORT SUMMARY

In this study, we aimed describe the effect of the intra-articular administration of stanozolol in a natural occurring canine osteoarthritis model. Forty (N=40) hip joints of active police working dogs were randomly assigned to a control (CG) and treatment (SG) group. Weight distribution, joint range of motion, thigh girth, digital thermography, radiographic signs, synovial fluid interleukin-1 levels were recorded at treatment day (day 0), and at 8, 15, 30, 90 and 180 days post-treatment. The Hudson Visual Analogue Scale, the Liverpool Osteoarthritis in Dogs, the Canine Brief Pain Inventory and the Canine Orthopedic Index. Results were compared using Repeated Measures ANOVA, with a Huynh-Feldt correction, Wilcoxon Signed Ranks Test, with p< 0.05.

Sample included joints from 40 pelvic limbs, graded as mild (n=36, 90%), moderate (n=2, 5%) and severe (n=2, 5%), with a mean age of 6.5±2.4 years and body weight of 26.7±5.2kg. No differences were found between groups at day 0. Comparing CG to SG, symmetry index showed significant improvements in SG from 15 days (p=0.05) up to 180 days (p=0.01). SG also showed lower values during thermographic evaluation in both views taken, and improved joint extension at 90 (p=0.02) and 180 days (p< 0.01). Pain and function scores, improved up to 90.180 days. In SG, improvements in some radiographic findings was observed.

To our knowledge, this is the first study to describe the effect of a single injection of stanozolol in a naturally occurring canine model, with a long follow up period.

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CHARACTERIZATION OF THE EFFECT OF THE INTRA-ARTICULAR ADMINISTRATION OF STANOZOLOL IN A NATURAL OCCURRING CANINE OSTEOARTHRITIS MODEL