To compare the effect of a single intra-articular administration of different treatments in a natural occurring canine osteoarthritis (OA) model, one hundred (N=100) hip joints with naturally occurring osteoarthritis (OA) and randomly assigned to five groups: control group (CG, n=20), triamcinolone hexacetonide group (THG, n=20), platelet concentrate group (PCG, n=20), stanozolol group (SG, n=20) and hylan G-F 20 group (HG). Evaluations were conducted on days 0 (treatment day), 8, 15, 30, 60, 90, 120, 150 and 180 days post treatment, and consisted of weight distribution analysis and data from four Clinical Metrology Instruments. Cox proportional hazard regression analysis was carried out to investigate the influence of the variables of interest on treatment survival. All results were analyzed with IBM SPSS Statistics version 20 and a significance level of p< 0.05 was set.
The sample included joints of 100 pelvic limbs (n=50 left and n=50 right), with a mean age of 6.5±2.4 years and body weight of 26.7±5.2kg, classified as mild (n=70), moderate (20) and severe (10). Patients in HG and PCG took longer to return to baseline values and scores. PCH and HG experienced 57%-81% improvements in functional evaluation and impairments due to OA, and may be a better options for these cases. Better impact on pain interference was observed in THG, with a 95% improvement over CG.
This study provides important information for the characterization of the effects of these treatment modalities, duration of observed improvements function and pain, in addition to information regarding candidates for each one.
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