Paper:

RESUMEN CORTO - SHORT SUMMARY

The aim of the study was to study if the adrenal carcinoma (AT) show association and correlated with neutered (Ox) and the age of Ox in female dogs.

Materials and methods: 47 female dogs with confirmed AT were selected and distributed into Ox (ATox, n=30) and not-Ox (AT, n=17). As controls, 35 Ox females (CGox) and 47 not-Ox (CG) without disease were included. The age (years) of Ox was established. Neutered dogs were divided into two groups as younger than 7 years (ATox, n=7; CG, n=19) and older than 7 years (ATox, n=23; CG, n=16) with the purpose to analyse whether the AT is associated with the OVx age. Mann-Whitney’s test, Fisher\'s exact test and Separman\'s correlation were used by the data analysis. Age are expressed as median and range, being significative P<0.05.

Results: The diagnosis age was in ATox 11 (5-15), AT 9.5 (7-13), age of CGox 6.5 (3-9); CG 6.8 (4-9), without significant differences. Neutered age in ATox 7 (1-12). Ox event and the age of OX (< or >7 years) showed statistical association P=0.028 (OR=0.42, 95%CI=0.2-0.88) and P=0.013 (OR=0.25, 95%CI=0.08-0.75) respectively. There was a correlation (r= -0.78; P<0.001) between age of Ox and AT.

Discussion and conclusion: The Ox and the age of Ox is associated with AT and increase the risk of AT. Dog’s adrenal cortex can overexpress LH receptors¹.The impact of increase LH on the adrenal cortex has been strongly associated in ferret with AT ². The same process would occur in female Ox dogs.

BIBLIOGRAFÍA

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GONADECTOMY AND ADRENAL CARCINOMA IN THE FEMALE DOG