A PRELIMINARY STUDY OF THE CLINICAL EFFICACY OF A SINGLE INTRA-ARTICULAR INFILTRATION WITH STANOZOLOL IN DOGS WITH KNEE DEGENERATIVE JOINT DISEASE AND ITS RELATIONSHIP WITH SERUM INTERLEUKIN-1Β

Type:
Free Communication
Topic:
Orthopaedics
Companies:
(1) Anjos of Assis Veterinary Medicine Centre - CMVAA
(2) Faculty of Veterinary Medicine, University of Lisbon (FMV/ULisboa)
(3) Interdisciplinary Centre for Research in Animal Health (CIISA) – University of Lisbon, (FMV/ULisboa)
(4) Divisão de Medicina Veterinária, Guarda Nacional Republicana (GNR).
(5) MED – Mediterranean Institute for Agriculture, Environment and Development, Instituto de Investigação e Formação Avançada, Universidade de Évora
Authors:
Miguel Carreira (1,2,3)
J. Alves (4,5)
J.p Sales Luís (2,3)
J. Cota (1)
P. Azevedo (1)
Paper:
RESUMEN CORTO - SHORT SUMMARY

Stanozolol is an anabolic and anti-catabolic promising molecule for the degenerative joint disease(DJD) condition. The study aimed to evaluate the clinical efficacy of a single intra-articular infiltration with Stanozolol in the treatment of canine knees with DJD and it relationship with serum IL-1β variation before and after the treatment. Twenty dogs divided into 2 groups were used: GDJD(with DJD) and GS(control group with healthy individuals). Four time-points were considered: T0(at the beginning of the protocol), T1,T2,T3(4th,8th,23rdday after injection). Brown query was used to assessment of chronic pain and quality of life in dog by tutors. All joints were radiographed at T0 and T3. Peripheral blood samples were collected to quantify the IL-1β level by using an ELISA method. Except for one patient, all the others showed at some point in the protocol a reduction in pain level intensity. Improvements were registered in 8 patients at T1, and 1 patient show the same only at T2. Pearson\'s correlation coefficient between pain level and IL-1β was positive in 8 patients(r=0.84; p<0.01). None of the GDJD had systemic anabolic or androgenic effects. The majority of patients (9/10) exhibited a decrease in the pain level of the infiltrated joint. This may be associated with the decrease in the synthesis of catabolic ILs, and with the increase of TGF-1β wich reduce pain level. This study is a pilot study evaluating the use of Stanozolol in canine DJD knees and its relationship with the IL-1β variation during treatment. Stanozolol seems to help-full in the management of degenerative joint disease in dogs.



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