Corticosteroids have been used for decades in human and veterinary emergency and critical care medicine. There are two major groups of corticosteroids: mineralocorticoids and glucocorticoids. Glucocorticoids are largely used as compared to mineralocorticoids. Mineralocorticoids exert aldosterone-like effects on the kidney, increasing sodium reabsorption and potassium secretion in the distal nephron. The glucocorticoids are most commonly used for their modulatory effects on the inflammatory and immune systems. Sepsis is a devastating condition for which there are few effective therapies. Contemporary treatment remains limited to early appropriate antibiotics, fluid resuscitation, hemodynamic support, and control of infection. The potential benefit of using steroids is biologically plausible. Corticosteroids are suggested for septic shock management. Extensive investigation into the efficacy of exogenous steroids have yielded variable outcomes. Although most prior investigations have examined the impact of glucocorticosteroid supplementation alone, it remains unclear whether concomitant mineralocorticoid administration may be of additional benefit.