CLINICAL EFFICACY OF A LIPID EXTRACT COLLAR IN FELINE ATOPIC SKIN SYNDROME: A CASE REPORT
(2) HOSPITAL VETERINARIO GLOBAL
Eliseo Zuriaga Sanchis (2)
Managing cats with allergic dermatitis can be frustrating for both the veterinarian and the tutor. In these cases, treatment compliance becomes a challenge. A 2.5-year-old spayed male domestic shorthair presented with a 6-month history of itching and hair loss which had not yet been treated. After examining the cat, performing the ancillary tests accordingly, and ruling out other potential causes for the pruritus and hair loss, feline atopic syndrome was diagnosed and topical treatment with a polymeric matrix collar containing a sphingomyelin-rich lipid extract was started. During the follow-up, the veterinarian reported an improvement in the SCORing Feline Allergic Dermatitis (SCORFAD) scale, which decreased from 5 (week 0) to 1 (week 4) and then down to 0 (week 8). On the other hand, the tutor reported improvements in the Pruritus Visual Analog Scale (PVAS), which started at 7 (week 0), and then went down to 5 (week 1) and 0 (week 2 and until 8 weeks). Provided the clinical benefits of the collar observed in this case, combining it with other skin health therapies could potentially allow for drug sparing, reduction of adverse effects, and lead to enhanced treatment compliance and reduced treatment costs. However, an adequate evaluation of the efficacy of this product in cats would be needed by performing the necessary clinical trials.
1. Halliwell, R. et al. Feline allergic diseases: introduction and proposed nomenclature. Vet. Dermatol. 32, 8-e2 (2021).
2. Vargo, C. & Banovic, F. Feline Atopic Skin Syndrome. Today’s Vet. Pract. 78–83 (2022).
3. Mueller, R. S., Nuttall, T., Prost, C., Schulz, B. & Bizikova, P. Treatment of the feline atopic syndrome – a systematic review. Vet. Dermatol. 32, 43-e8 (2021).
4. Cerrato, S. et al. Effects of sphingolipid extracts on the morphological structure and lipid profile in an in vitro model of canine skin. Vet. J. 212, 58–64 (2016).
5. Segarra, S., Bernard, F.-X., Flores, J. & Naiken, T. Effects of sphingolipids, glycosaminoglycans, and their combination on in vitro filaggrin expression using reconstructed human epidermis. In: Abstracts of the 30th Annual Congress of the ECVD-ESVD, Dubrovnik, Croatia. Vet. Dermatol. 29, 372 (2018).
6. Segarra, S., Bernard, F.-X. & Naiken, T. Sphingolipids and glycosaminoglycans modulate the expression of antimicrobial peptides in keratinocytes under basal conditions. in Proceedings of the Southern European Veterinary Conference: 18-20 October 2018, Madrid, Spain (2018).
7. Marsella, R., Segarra, S., Ahrens, K., Alonso, C. & Ferrer, L. Topical treatment with sphingolipids and glycosaminoglycans for canine atopic dermatitis. BMC Vet. Res. 16, 1–10 (2020).
8. Segarra, S. et al. Clinical effects of a sphingolipid collar in client-owned dogs with naturally occurring atopic dermatitis: a pilot study. in Proceedings of the North American Veterinary Dermatology Forum: April 27-30, 2022, New Orleans, Lousiana 156 (2022).
9. Steffan, J., Olivry, T., Forster, S. L. & Seewald, W. Responsiveness and validity of the SCORFAD, an extent and severity scale for feline hypersensitivity dermatitis. Vet. Dermatol. 23, (2012).
