LDH: a new tool to suspect canine hypothyroidism?

Type:
Scientific Communication
Topic:
Endocrinology
Companies:
(1) Interlab-UMU, Regional Campus of International Excellence “Mare Nostrum” University of Murcia, 30100 Murcia, Spain
(2) Clinic for Internal Diseases, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 1000 Za-greb, Croatia
(3) Department of Animal and Food Science, School of Veterinary Science, Universitat Autònoma de Barcelo-na, 08193 Cerdanyola del Vallès, Barcelona, Spain
Authors:
Luis Guillermo González Arostegui (1)
Alberto Muñoz Prieto (2)
Asta Tvarijonaviciute (1)
Camila Peres Rubio (3)
José Joaquín Cerón Madrigal (1)
RESUMEN CORTO - SHORT SUMMARY:

Hypothyroidism is the most common endocrine disorder in dogs. Diagnosis of hypothyroidism is based on circulating thyroid hormone concentrations, but their measurement does not always lead to a clear diagnosis, since hormones can be found within range in some cases. Lactate dehydrogenase (LDH), an enzyme that helps to maintain homeostasis under anaerobic conditions, has been described to be increased in humans with hypothyroidism. The objective of this study is to evaluate the possible changes of LDH in the serum of dogs with hypothyroidism compared to dogs with non-thyroidal illnesses and healthy dogs. For this purpose, a total of 43 dogs were included in this study:  23 dogs diagnosed with hypothyroidism, 23 dogs with non-thyroidal illnesses and 16 healthy control dogs.  LDH activity was measured in serum by an automated spectrophotometric assay using a commercially available kit. 

Results showed a statistically significantly higher LDH values in dogs with hypothyroidism (> 0.001) in comparison to healthy controls, however, no significant differences were found in with respect to the non-thyroidal illnesses group. Our results show that the measurement of LDH could be an additional tool together with the rest of the clinical information to include the presence of hypothyroidism in the differentials of a clinical case, making it a helpful biomarker for further investigations. 

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