Acute Polyradiculoneuritis is one of the most commonly recognized canine peripheral neuropathies and is regarded as the canine equivalent of the acute human neuropathy, Guillain-Barre ́ syndrome (GBS) The typical clinical scenario for AIP describes a rapidly developing flaccid paresis/plegia, usually beginning in the pelvic limbs and eventually involving the thoracic limbs. Most affected animals will be either non-ambulatory tetraparetic or tetraplegic within ten days of the initial onset of clinical signs. It is not uncommon to reach this dysfunction stage within the first 72-hour. The development of life-threatening respiratory paralysis is a concern, especially in the more rapidly progressing cases. Aphonia or dysphonia is common, and some patients will also exhibit facial weakness. Dogs in the progressive stage of the disease (especially during the first 4–5 days) should be closely monitored in the hospital for respiratory problems. Animals showing severe respiratory compromise should be placed in intensive care and may require mechanical ventilation. Diagnosis is typically based upon the signalment, history, and characteristic clinical signs of a rapidly progressive polyneuropathy. However, the differential diagnosis must include other causes of polyneuropathy. There is no specific therapy for this disease. Nursing care, physical therapy, and proper nutrition are essential for recovery. The prognosis for full recovery is often favourable.