We prospectively evaluated feasibility, effectiveness, complications, and long-term follow-up of minimally invasive rhinoscopic laser ablation of residual intranasal tumor mass after previous curative intent external beam megavoltage radiation therapy in dogs. Dogs with residual/recurrent intranasal tumor on CT evaluation 3 months after radiation therapy were offered surgical reduction/removal of the mass by laser ablation through a normograde or retrograde rhinoscopy approach. Follow-up rhinoscopic evaluation with the option of repeated laser surgery if indicated, was advised in all cases and was performed at the courtesy of the owner.