Analgesic management is crucial in exotic pets undergoing surgical procedures and affected by painful conditions. Pain treatment is essential for the exotic patient welfare and to improve the quality of recovery after surgery. It is also vital to reduce morbidity and mortality associated with untreated pain. Pain assessment can be extremely challenging in animals due to their inability to verbally communicate pain, as well as prey species’ tendency to hide or mask outward signs of disease. The extrapolation of drugs is generally discouraged due to the wide differences existing in the pharmacokinetics and pharmacodynamics of analgesic drugs between exotic animal species. Many of these analgesics and locoregional techniques may also lack evidence in their ability to treat pain. The Multimodal Approach to analgesia aims to optimizes pain relief by combining different known analgesics with different mechanisms of action, such as: - Opioids - Nonsteroidal Anti-inflammatory Drugs (NSAIDs) - Local Anesthetics Luckily, a growing body of scientific research is contributing to the movement towards an evidence-based approach in the design and developments in exotic pet analgesia.