Dermatological disorders are some of the most common problems affecting exotic companion mammals (ECM). They can have an infectious (parasites, fungi, bacteria and viruses) or non-infectious (neoplastic, behavioral, idiopathic, husbandry-related) origin. Affected animals may present with several clinical signs such as alopecia, pruritus, crusting, scaling, papules, nodules, erosion and ulceration. These clinical signs are often presented simultaneously and therefore a full diagnostic workup (history, clinical examination, clinical pathology, imaging diagnostic tests) is needed to achieve a final diagnosis. Currently there are a limited number of drugs can be used to treat ECM, due to a lack of information on pharmacodynamics and pharmacokinetics of those drugs used in dogs and cats, their potential adverse effects in herbivore species as well as species-specific sensitivity to steroids. However, more and new therapeutic treatments are currently investigated in several species of ECM.