Prostate carcinoma (PCA) in dogs has a poor prognosis due to location, invasive growth of the tumor, high metastasis rate, and high complication rates from local treatments. Surgery +/- adjuvant treatments for PCA in dogs has historically been met with high complication rates and poor prognosis. However, complications of total prostatectomy (TP) for PCA in men have been significantly reduced and clinical outcome improved with the development of nerve-sparing TP procedures. Recent reports of TP in dogs with PCA show promising clinical results. This lecture will present and discuss TP technique in dogs with PCA, comparative aspects, and clinical outcome at the authors institution.